J. Kim, D. Cornish, A. Ali; TrilliumBiO, Rockville, MD, United States.

Rationale: Detection of autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) in human serum plays a pivotal role in the diagnosis and monitoring of individuals with autoimmune pulmonary alveolar proteinosis (aPAP). aPAP is a rare pulmonary disease characterized by abnormal accumulation of surfactant within the alveoli which may lead to hypoxemia and in rare cases, respiratory failure. Ensuring the reliability and precision of the laboratory test is essential for its clinical utility. In this study, we present the development and performance characteristics of a novel laboratory test for the detection of GM-CSF autoantibodies in human serum.

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