— Data on a novel laboratory assay to detect GM-CSF autoantibodies from dried blood spots (DBS) advances the validity of testing and increases access for patients —
Rockville, Maryland — October 22, 2025 — TrilliumBiO, today announced the presentation of the poster “Development of a dried blood spot assay for the detection of GM-CSF autoantibodies to aid in the diagnosis of autoimmune pulmonary alveolar proteinosis” at The American College of Chest Physicians (CHEST) 2025 Annual Meeting, October 19 – October 22, Chicago, Illinois.
This study was conducted to develop and validate a novel laboratory assay to detect granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies from dried blood spots obtained using the ADX100 serum separator card. This approach facilitates easy transport and storage of patient samples, thereby expanding access to testing. TrilliumBiO developed the particle-based flow cytometry immunoassay in collaboration with Savara Inc. and Cincinnati Translational Pulmonary Science Center.
Strong correlations were observed between GM-CSF autoantibody levels measured in serum from venipuncture and those measured using ADX100 (DBS) samples. The study involved three independent analyses and demonstrated robust analytical precision. Offering an accessible method to aid in the diagnosis of autoimmune pulmonary alveolar proteinosis, this assay represents a significant advancement in the detection of this rare lung disease.
About TrilliumBiO
TrilliumBiO is a life sciences company specializing in biomarker discovery and the development and commercialization of novel diagnostic tests in collaboration with healthcare innovators. With a proven track record of translating clinical insights into market-ready solutions, TrilliumBiO delivers validated, physician-guided diagnostics that address complex medical challenges. Backed by strong research partnerships and a commitment to evidence-based development, TrilliumBiO transforms discovery into actionable innovations that inform real-world clinical decisions. More information about TrilliumBiO can be found at www.TrilliumBiO.com.
Thiruppathi E, Kim J, Djidotor R, Ali A, Carey BC, Trapnell BC. Development of a dried blood spot assay for the detection of GM-CSF autoantibodies to aid in the diagnosis of autoimmune pulmonary alveolar proteinosis. Poster presented at: CHEST 2025, Chicago, Illinois. Wednesday, October 22, 2025.
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